Briefing | Trans substantiation

The evidence to support medicalised gender transitions in adolescents is worryingly weak

The effectiveness and side-effects of the most common treatments are not well understood

PRISHA MOSLEY was 17 when she was first given testosterone in a clinic in North Carolina, after she had declared to her parents that she was a boy. She had struggled through her teen years with anorexia and depression after a sexual assault. Luka Hein had both breasts removed as a 16-year-old in Nebraska. Chloe Cole, in California, was a year younger when she had her double mastectomy. She had been on testosterone and puberty-blocking drugs since 13, also after a sexual assault.

This article appeared in the Briefing section of the print edition under the headline “Trans substantiation”

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